Article
Correlation of somatic mutations with outcome after FLAMSA-busulfan sequential conditioning and allogeneic stem cell transplantation in patients with myelodysplastic syndromes.
European journal of haematology - 1 Sept 2016
Christopeit Maximilian, Badbaran Anita, Alawi Malik, Zabelina Tatjana, Zeck Gaby, Wolschke Christine, Ayuk Francis, Kröger Nicolaus
Abstract excerpt
Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a curative treatment option for myelodysplastic syndromes (MDS). Little is known about the prognostic impact of mutations, for example, in TP53 specifically after allo-HSCT. We here describe the prognostic impact of mutations in a panel of 19 genes analyzed by amplicon-based next-generation-sequencing in a uniformly treated patient cohort....
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