Favorable impact of allogeneic stem cell transplantation in patients with therapy-related myelodysplasia regardless of TP53 mutational status.

doi:10.3324/haematol.2017.172544

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Article

Favorable impact of allogeneic stem cell transplantation in patients with therapy-related myelodysplasia regardless of TP53 mutational status.

Haematologica - 1 Dec 2017

Aldoss Ibrahim, Pham Anh, Li Sierra Min, Gendzekhadze Ketevan, Afkhami Michelle, Telatar Milhan, Hong Hao, Padeganeh Abbas, Bedell Victoria, Cao Thai, Khaled Samer K, Malki Monzr M Al, Salhotra Amandeep, Ali Haris, Aribi Ahmed, Palmer Joycelynne, Aoun Patricia, Spielberger Ricardo, Stein Anthony S, Snyder David, O'Donnell Margaret R, Murata-Collins Joyce, Senitzer David, Weisenburger Dennis, Forman Stephen J, Pullarkat Vinod, Marcucci Guido, Pillai Raju, Nakamura Ryotaro

Abstract excerpt

Therapy-related myelodysplastic syndrome is a long-term complication of cancer treatment in patients receiving cytotoxic therapy, characterized by high-risk genetics and poor outcomes. Allogeneic hematopoietic cell transplantation is the only potential cure for this disease, but the prognostic impact of pre-transplant genetics and clinical features has not yet been fully characterized. We report here the genetic...

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Identifiers

PMID: 28971906
DOI: 10.3324/haematol.2017.172544
PMCID: PMC5709102

Genes

ASXL1
ETV6
RUNX1

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