Article
Heat shock protein 70 gene polymorphisms' influence on the electrophysiology of long QT syndrome.
Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing - 1 Mar 2016
Ali Altaf, Qureshi Sameera F, Medikare Veronica, Venkateshwari Ananthapur, Calambur Narsimhan, Rao Hygriv, Jayakrishnan M P, Shenthar Jayaprakash, Thangaraj Kumarasamy, Nallari Pratibha
Abstract excerpt
PURPOSE: Long QT syndrome (LQTS) is a rare cardiac disorder caused due to mutations in genes encoding ion channels responsible for generation of electrical impulses. The heat shock protein (HSP)-70 gene, expressed under conditions of stress, plays a cardioprotective role when overexpressed and helps in the proper folding of the nascent proteins synthesized by the cellular machinery. We aimed to identify the role...
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