Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.

doi:10.1371/journal.pone.0145105

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Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.

PloS one - 1 Jan 2015

About Frédégonde, Oudot-Mellakh Tiphaine, Niay Jonathan, Rabiéga Pascaline, Pedergnana Vincent, Duffy Darragh, Sultanik Philippe, Cagnot Carole, Carrat Fabrice, Marcellin Patrick, Zoulim Fabien, Larrey Dominique, Hézode Christophe, Fontaine Hélène, Bronowicki Jean-Pierre, Pol Stanislas, Albert Matthew L, Theodorou Ioannis, Cobat Aurélie, Abel Laurent

Abstract excerpt

BACKGROUND: Human genetic factors influence the outcome of pegylated interferon and ribavirin hepatitis C therapy. We explored the role of IL28B, APOH and ITPA SNPs on the outcomes of triple therapy including telaprevir or boceprevir in patients with compensated cirrhosis chronically infected with HCV-1. PATIENTS AND METHODS: A total of 256 HCV-1 Caucasian treatment-experienced patients with compensated cirrhosis...

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PMID: 26670100
DOI: 10.1371/journal.pone.0145105
PMCID: PMC4682920

Genes

APOH
ITPA
BOC

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Impact of IL28B, APOH and ITPA Polymorphisms on Efficacy and Safety of TVR- or BOC-Based Triple Therapy in Treatment-Experienced HCV-1 Patients with Compensated Cirrhosis from the ANRS CO20-CUPIC Study.PMID 26670100Read ↗

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