Article
Dexamethasone treatment alters insulin, leptin, and adiponectin levels in male mice as observed in DIO but does not lead to alterations of metabolic phenotypes in the offspring.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2016
Bönisch Clemens, Irmler Martin, Brachthäuser Laura, Neff Frauke, Bamberger Mareike T, Marschall Susan, Hrabě de Angelis Martin, Beckers Johannes
Abstract excerpt
Epigenetic inheritance (EI) of metabolic phenotypes via the paternal lineage has been shown in rodent models of diet-induced obesity (DIO). However, the factors involved in soma-to-germline information transfer remain elusive. Here, we address the role of alterations in insulin, leptin, and adiponectin levels for EI of metabolic phenotypes by treating C57BL/6NTac male mice (F0) with the synthetic glucocorticoid...
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