Article
The GPSM2/LGN GoLoco motifs are essential for hearing.
Mammalian genome : official journal of the International Mammalian Genome Society - 1 Feb 2016
Bhonker Yoni, Abu-Rayyan Amal, Ushakov Kathy, Amir-Zilberstein Liat, Shivatzki Shaked, Yizhar-Barnea Ofer, Elkan-Miller Tal, Tayeb-Fligelman Einav, Kim Sun Myoung, Landau Meytal, Kanaan Moien, Chen Ping, Matsuzaki Fumio, Sprinzak David, Avraham Karen B
Abstract excerpt
The planar cell polarity (PCP) pathway is responsible for polarizing and orienting cochlear hair cells during development through movement of a primary cilium, the kinocilium. GPSM2/LGN, a mitotic spindle-orienting protein associated with deafness in humans, is a PCP effector involved in kinocilium migration. Here, we link human and mouse truncating mutations in the GPSM2/LGN gene, both leading to hearing loss....
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