Article
Construction of relatedness matrices using genotyping-by-sequencing data.
BMC genomics - 9 Dec 2015
Dodds Ken G, McEwan John C, Brauning Rudiger, Anderson Rayna M, van Stijn Tracey C, Kristjánsson Theodor, Clarke Shannon M
Abstract excerpt
BACKGROUND: Genotyping-by-sequencing (GBS) is becoming an attractive alternative to array-based methods for genotyping individuals for a large number of single nucleotide polymorphisms (SNPs). Costs can be lowered by reducing the mean sequencing depth, but this results in genotype calls of lower quality. A common analysis strategy is to filter SNPs to just those with sufficient depth, thereby greatly reducing the...
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