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Article

GGGGCC microsatellite RNA is neuritically localized, induces branching defects, and perturbs transport granule function

9 Dec 2015

Abstract excerpt

Microsatellite expansions are the leading cause of numerous neurodegenerative disorders. Here we demonstrate that GGGGCC and CAG microsatellite repeat RNAs associated with C9orf72 in amyotrophic lateral sclerosis/frontotemporal dementia and with polyglutamine diseases, respectively, localize to neuritic granules that undergo active transport into distal neuritic segments. In cultured mammalian spinal cord...

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PMID: 26650351
DOI: 10.7554/elife.08881

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