Article
Intranuclear inclusions and neuritic aggregates in transgenic mice expressing a mutant N-terminal fragment of huntingtin.
Human molecular genetics - 1 Mar 1999
Schilling G, Becher M W, Sharp A H, Jinnah H A, Duan K, Kotzuk J A, Slunt H H, Ratovitski T, Cooper J K, Jenkins N A, Copeland N G, Price D L, Ross C A, Borchelt D R
Abstract excerpt
Huntington's disease (HD) is an inherited, neurodegenerative disorder caused by the expansion of a glutamine repeat in the N-terminus of the huntingtin protein. To gain insight into the pathogenesis of HD, we generated transgenic mice that express a cDNA encoding an N-terminal fragment (171 amino...
Topics
- Animals
- Base Sequence
- Cell Nucleus
- DNA Primers
- Disease Models, Animal
- Humans
- Huntingtin Protein
- Huntington Disease
- Inclusion Bodies
- Mice
- Mice, Transgenic
- Nerve Tissue Proteins
- Neurites
- Nuclear Proteins