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Article

Beta-elemene blocks epithelial-mesenchymal transition in human breast cancer cell line MCF-7 through Smad3-mediated down-regulation of nuclear transcription factors.

PloS one - 1 Jan 2013

Zhang Xian, Li Yinghua, Zhang Yang, Song Jincheng, Wang Qimin, Zheng Luping, Liu Dan

Abstract excerpt

Epithelial-mesenchymal transition (EMT) is the first step required for breast cancer to initiate metastasis. However, the potential of drugs to block and reverse the EMT process are not well explored. In the present study, we investigated the inhibitory effect of beta-elemene (ELE), an active component of a natural plant-derived anti-neoplastic agent in an established EMT model mediated by transforming growth...

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Identifiers

PMID: 23516540
DOI: 10.1371/journal.pone.0058719
PMCID: PMC3597725

Genes

SNAI1
SNAI2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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