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Article

Ethambutol plasma and intracellular pharmacokinetics: A pharmacogenetic study.

International journal of pharmaceutics - 30 Jan 2016

Fatiguso Giovanna, Allegra Sarah, Calcagno Andrea, Baietto Lorena, Motta Ilaria, Favata Fabio, Cusato Jessica, Bonora Stefano, Perri Giovanni Di, D'Avolio Antonio

Abstract excerpt

We evaluated ethambutol plasma and intracellular pharmacokinetic according to single nucleotide polymorphisms in ABCB1, OATP1B1, PXR, VDR, CYP24A1 and CYP27B1 genes. Mycobacterium tubercolosis infected patients were enrolled. Standard weight-adjusted antitubercular treatment was administered intravenously for 2 weeks and then orally. Allelic discrimination was performed by real-time PCR. Ethambutol plasma and...

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Source

Identifiers

PMID: 26642947
DOI: 10.1016/j.ijpharm.2015.11.044

Genes

ABCB1
VDR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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