Article
Combined Delivery of Let-7b MicroRNA and Paclitaxel via Biodegradable Nanoassemblies for the Treatment of KRAS Mutant Cancer.
Molecular pharmaceutics - 1 Feb 2016
Dai Xin, Fan Wei, Wang Yingzhe, Huang Lijie, Jiang Ying, Shi Lei, Mckinley DeAngelo, Tan Wen, Tan Chalet
Abstract excerpt
In the present study, we synthesized a novel cationic copolymer composed of polyethylene glycol 5000 (PEG5K), vitamin E (VE), and diethylenetriamine (DET) at 1:4:20 molar ratio. The resulting PEG5K-VE4-DET20 copolymer formed nanoassemblies when mixed with the neutral PEG5K-VE4 copolymer at 1:8 weight ratio, which were investigated as the nanocarriers for combined delivery of paclitaxel and let-7b mimic. We found...
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