Article
Combination of siRNA-directed Kras oncogene silencing and arsenic-induced apoptosis using a nanomedicine strategy for the effective treatment of pancreatic cancer.
Nanomedicine : nanotechnology, biology, and medicine - 1 Feb 2014
Zeng Linjuan, Li Jingguo, Wang Yong, Qian Chenchen, Chen Yinting, Zhang Qiubo, Wu Wei, Lin Zhong, Liang Jianzhong, Shuai Xintao, Huang Kaihong
Abstract excerpt
The synergetic inhibitory effects on human pancreatic cancer by nanoparticle-mediated siRNA and arsenic therapy were investigated both in vitro and in vivo. Poly(ethylene glycol)-block-poly(L-lysine) were prepared to form siRNA-complexed polyplex and poly(ethylene glycol)-block-poly(DL-lactide) were prepared to form arsenic-encapsulated vesicle, respectively. Down-regulation of the mutant Kras gene by siRNA...
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