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Article

BAP1 suppresses prostate cancer progression by deubiquitinating and stabilizing PTEN

6 Nov 2020

Abstract excerpt

Deubiquitinase BAP1 is an important tumor suppressor in several malignancies, but its functions and critical substrates in prostate cancer (PCa) remain unclear. Here, we report that the mRNA and protein expression levels of BAP1 are downregulated in clinical PCa specimens. BAP1 can physically bind to and deubiquitinate PTEN, which inhibits the ubiquitination-mediated degradation of PTEN and thus stabilizes PTEN...

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PMID: 33155366
DOI: 10.1002/1878-0261.12844

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