Article
Observed and expected frequencies of structural hemoglobin variants in newborn screening surveys in Africa and the Middle East: deviations from Hardy-Weinberg equilibrium.
Genetics in medicine : official journal of the American College of Medical Genetics - 1 Mar 2016
Piel Frédéric B, Adamkiewicz Thomas V, Amendah Djesika, Williams Thomas N, Gupta Sunetra, Grosse Scott D
Abstract excerpt
PURPOSE: Our objective was to compare observed and expected genotype proportions from newborn screening surveys of structural hemoglobin variants. METHODS: We conducted a systematic review of newborn screening surveys of hemoglobins S and C in Africa and the Middle East. We compared observed frequencies to those expected assuming Hardy-Weinberg equilibrium (HWE). Significant deviations were identified by an exact...
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