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Article

Molecular Evolution of the TET Gene Family in Mammals.

International journal of molecular sciences - 1 Dec 2015

Akahori Hiromichi, Guindon Stéphane, Yoshizaki Sumio, Muto Yoshinori

Abstract excerpt

Ten-eleven translocation (TET) proteins, a family of Fe(2+)- and 2-oxoglutarate-dependent dioxygenases, are involved in DNA demethylation. They also help regulate various cellular functions. Three TET paralogs have been identified (TET1, TET2, and TET3) in humans. This study focuses on the evolution of mammalian TET genes. Distinct patterns in TET1 and TET2 vs. TET3 were revealed by codon-based tests of positive...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 26633372
DOI: 10.3390/ijms161226110
PMCID: PMC4691057

Genes

TET2
TET3
TET1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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