Article
DICER1 and microRNA regulation in post-traumatic stress disorder with comorbid depression.
Nature communications - 3 Dec 2015
Wingo Aliza P, Almli Lynn M, Stevens Jennifer S, Stevens Jennifer J, Klengel Torsten, Uddin Monica, Li Yujing, Bustamante Angela C, Lori Adriana, Koen Nastassja, Stein Dan J, Smith Alicia K, Aiello Allison E, Koenen Karestan C, Wildman Derek E, Galea Sandro, Bradley Bekh, Binder Elisabeth B, Jin Peng, Gibson Greg, Ressler Kerry J
Abstract excerpt
DICER1 is an enzyme that generates mature microRNAs (miRNAs), which regulate gene expression post-transcriptionally in brain and other tissues and is involved in synaptic maturation and plasticity. Here, through genome-wide differential gene expression survey of post-traumatic stress disorder (PTSD) with comorbid depression (PTSD&Dep), we find that blood DICER1 expression is significantly reduced in cases versus...
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