Article
High-Throughput Mutation Profiling Changes before and 3 Weeks after Chemotherapy in Newly Diagnosed Breast Cancer Patients.
PloS one - 1 Jan 2015
Tan Sing-Huang, Sapari Nur Sabrina, Miao Hui, Hartman Mikael, Loh Marie, Chng Wee-Joo, Iau Philip, Buhari Shaik Ahmad, Soong Richie, Lee Soo-Chin
Abstract excerpt
BACKGROUND: Changes in tumor DNA mutation status during chemotherapy can provide insights into tumor biology and drug resistance. The purpose of this study is to analyse the presence or absence of mutations in cancer-related genes using baseline breast tumor samples and those obtained after exposure to one cycle of chemotherapy to determine if any differences exist, and to correlate these differences with...
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