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Article

Modeling the Transitions between Collective and Solitary Migration Phenotypes in Cancer Metastasis

2 Dec 2015

Abstract excerpt

Cellular plasticity during cancer metastasis is a major clinical challenge. Two key cellular plasticity mechanisms -Epithelial-to-Mesenchymal Transition (EMT) and Mesenchymal-to-Amoeboid Transition (MAT) - have been carefully investigated individually, yet a comprehensive understanding of their interconnections remains elusive. Previously, we have modeled the dynamics of the core regulatory circuits for both EMT...

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PMID: 26627083
DOI: 10.1038/srep17379

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