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Article

Cardiac denervation evidenced by MIBG occurs earlier than amyloid deposits detection by diphosphonate scintigraphy in TTR mutation carriers.

European journal of nuclear medicine and molecular imaging - 1 Jul 2018

Piekarski Eve, Chequer Renata, Algalarrondo Vincent, Eliahou Ludivine, Mahida Besma, Vigne Jonathan, Adams David, Slama Michel S, Le Guludec Dominique, Rouzet Francois

Abstract excerpt

PURPOSE: Cardiac involvement in familial transthyretin (TTR) amyloidosis is of major prognostic value, and the development of early-diagnostic tools that could trigger the use of new disease-modifying treatments is crucial. The aim of our study was to compare the respective contributions of 99mTc-diphosphonate scintigraphy (DPD, detecting amyloid deposits) and 123I-MIBG (MIBG, assessing cardiac sympathetic...

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Share to Amyloid Neuropathies, Familial
Share to Denervation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Diphosphonates

Share to Plaque, Amyloid

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Share to Radionuclide Imaging

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Source

Identifiers

PMID: 29511839
DOI: 10.1007/s00259-018-3963-x

Genes

TTR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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