Article
16p11.2 Locus modulates response to satiety before the onset of obesity.
International journal of obesity (2005) - 1 May 2016
Maillard A M, Hippolyte L, Rodriguez-Herreros B, Chawner S J R A, Dremmel D, Agüera Z, Fagundo A B, Pain A, Martin-Brevet S, Hilbert A, Kurz S, Etienne R, Draganski B, Jimenez-Murcia S, Männik K, Metspalu A, Reigo A, Isidor B, Le Caignec C, David A, Mignot C, Keren B, van den Bree M B M, Munsch S, Fernandez-Aranda F, Beckmann J S, Reymond A, Jacquemont S
Abstract excerpt
BACKGROUND: The 600 kb BP4-BP5 copy number variants (CNVs) at the 16p11.2 locus have been associated with a range of neurodevelopmental conditions including autism spectrum disorders and schizophrenia. The number of genomic copies in this region is inversely correlated with body mass index (BMI): the deletion is associated with a highly penetrant form of obesity (present in 50% of carriers by the age of 7 years...
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