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Article

Phosphorylation negatively regulates exosome mediated secretion of cryAB in glioma cells.

Biochimica et biophysica acta - 1 Feb 2016

Kore Rajshekhar A, Abraham Edathara C

Abstract excerpt

Exosomes mediate secretion of crystallin alphaB (cryAB), a well characterized molecular chaperone with anti-apoptotic activity. However, the mechanisms governing its packaging and secretion remained unexplored. In glioma cells, notwithstanding extensive phosphorylation of cryAB at Ser59 followed by Ser45 (Ser19 is largely unphosphorylated), we discovered that the majority of secreted exosomal cryAB is...

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Identifiers

PMID: 26620801
DOI: 10.1016/j.bbamcr.2015.11.027
PMCID: PMC6374115

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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