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Article

Conservation and Role of Electrostatics in Thymidylate Synthase.

Scientific reports - 27 Nov 2015

Garg Divita, Skouloubris Stephane, Briffotaux Julien, Myllykallio Hannu, Wade Rebecca C

Abstract excerpt

Conservation of function across families of orthologous enzymes is generally accompanied by conservation of their active site electrostatic potentials. To study the electrostatic conservation in the highly conserved essential enzyme, thymidylate synthase (TS), we conducted a systematic species-based comparison of the electrostatic potential in the vicinity of its active site. Whereas the electrostatics of the...

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Identifiers

PMID: 26612036
DOI: 10.1038/srep17356
PMCID: PMC4661567

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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