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Article

Surgery is associated with ventricular enlargement as well as cognitive and functional decline.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 May 2016

Schenning Katie J, Murchison Charles F, Mattek Nora C, Silbert Lisa C, Kaye Jeffrey A, Quinn Joseph F

Abstract excerpt

INTRODUCTION: In preclinical studies, surgery/anesthesia contribute to cognitive decline and enhance neuropathologic changes underlying Alzheimer's disease (AD). Nevertheless, the link between surgery, anesthesia, apolipoprotein E ε4 (APOE ε4), and AD remains unclear. METHODS: We performed a retrospective cohort analysis of two prospective longitudinal aging studies. Mixed-effects statistical models were used to...

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Identifiers

PMID: 26610898
DOI: 10.1016/j.jalz.2015.10.004
PMCID: PMC4861667

Genes

APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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