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High-Level Production of Human Papillomavirus (HPV) Type 16 L1 in Escherichia coli

28 Feb 2016

Abstract excerpt

Human papillomavirus (HPV), a non-enveloped, double-stranded DNA tumor virus, is a primary etiological agent of cervical cancer development. As a potential tool for prophylactic vaccination, the development of virus-like particles (VLPs) containing the HPV16 L1 capsid protein is highly desired. In this study, we developed a high-level expression system of the HPV16 L1 in Escherichia coli for the purpose of VLP...

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PMID: 26608168
DOI: 10.4014/jmb.1511.11010

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