Lamination Speeds the Functional Development of Visual Circuits.

Abstract excerpt

A common feature of the brain is the arrangement of synapses in layers. To examine the significance of this organizational feature, we studied the functional development of direction-selective (DS) circuits in the tectum of astray mutant zebrafish in which lamination of retinal ganglion cell (RGC) axons is lost. We show that although never laminar, the tuning of DS-RGC axons targeting the mutant tectum is normal....

Topics

• Animals
• Animals, Genetically Modified
• Electroporation
• Gene Expression Regulation, Developmental
• Larva
• Mutation
• Nerve Net
• Orientation
• Receptors, Immunologic
• Retina
• Retinal Ganglion Cells
• Superior Colliculi