Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines.

doi:10.1186/s13046-015-0259-x

Article

Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines.

Journal of experimental & clinical cancer research : CR - 25 Nov 2015

Skowron Margaretha A, Niegisch Günter, Fritz Gerhard, Arent Tanja, van Roermund Joep G H, Romano Andrea, Albers Peter, Schulz Wolfgang A, Hoffmann Michèle J

Abstract excerpt

BACKGROUND: Tumour heterogeneity and resistance to systemic treatment in urothelial carcinoma (UC) may arise from cancer stem cells (CSC). A recent model describes cellular differentiation states within UC based on corresponding expression of surface markers (CD) and cytokeratins (CK) with CD90 and CK14 positive cells representing the least differentiated and most tumourigenic population. Based on the fact that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Phenotype plasticity rather than repopulation from CD90/CK14+ cancer stem cells leads to cisplatin resistance of urothelial carcinoma cell lines.

Abstract excerpt

Topics

Related research