Article
Phenotypic and Functional Properties of Human Steady State CD14+ and CD1a+ Antigen Presenting Cells and Epidermal Langerhans Cells.
PloS one - 1 Jan 2015
Fehres Cynthia M, Bruijns Sven C M, Sotthewes Brigit N, Kalay Hakan, Schaffer Lana, Head Steven R, de Gruijl Tanja D, Garcia-Vallejo Juan J, van Kooyk Yvette
Abstract excerpt
Cutaneous antigen presenting cells (APCs) are critical for the induction and regulation of skin immune responses. The human skin contains phenotypically and functionally distinct APCs subsets that are present at two separated locations. While CD1ahigh LCs form a dense network in the epidermis, the CD14+ and CD1a+ APCs reside in the dermal compartment. A better understanding of the biology of human skin APC...
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