Article
Elevated IL-15 concentrations in the sarcoidosis lung are independent of granuloma burden and disease phenotypes.
American journal of physiology. Lung cellular and molecular physiology - 1 Jun 2021
Minasyan Maksym, Sharma Lokesh, Pivarnik Taylor, Liu Wei, Adams Taylor, Bermejo Santos, Peng Xiaohua, Liu Angela, Ishikawa Genta, Perry Carrighan, Kaminski Naftali, Gulati Mridu, Herzog Erica L, Dela Cruz Charles S, Ryu Changwan
Abstract excerpt
Sarcoidosis is a systemic granulomatous disease predominantly affecting the lungs. The mechanisms promoting disease pathogenesis and progression are unknown, although interleukin-15 (IL-15) has been associated with the immune-mediated inflammation of sarcoidosis. Because the identification of a mechanistically based, clinically relevant biomarker for sarcoidosis remains elusive, we hypothesized this role for...
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