Article
A Simple Proteomics-Based Approach to Identification of Immunodominant Antigens from a Complex Pathogen: Application to the CD4 T Cell Response against Human Herpesvirus 6B.
PloS one - 1 Jan 2015
Becerra-Artiles Aniuska, Dominguez-Amorocho Omar, Stern Lawrence J, Calvo-Calle J Mauricio
Abstract excerpt
Most of humanity is chronically infected with human herpesvirus 6 (HHV-6), with viral replication controlled at least in part by a poorly characterized CD4 T cell response. Identification of viral epitopes recognized by CD4 T cells is complicated by the large size of the herpesvirus genome and a low frequency of circulating T cells responding to the virus. Here, we present an alternative to classical epitope...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.