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Article

Locked Nucleic Acid Probe-Based Real-Time PCR Assay for the Rapid Detection of Rifampin-Resistant Mycobacterium tuberculosis.

PloS one - 1 Jan 2015

Zhao Yong, Li Guilian, Sun Chongyun, Li Chao, Wang Xiaochen, Liu Haican, Zhang Pingping, Zhao Xiuqin, Wang Xinrui, Jiang Yi, Yang Ruifu, Wan Kanglin, Zhou Lei

Abstract excerpt

Drug-resistant Mycobacterium tuberculosis can be rapidly diagnosed through nucleic acid amplification techniques by analyzing the variations in the associated gene sequences. In the present study, a locked nucleic acid (LNA) probe-based real-time PCR assay was developed to identify the mutations in the rpoB gene associated with rifampin (RFP) resistance in M. tuberculosis. Six LNA probes with the discrimination...

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Identifiers

PMID: 26599667
DOI: 10.1371/journal.pone.0143444
PMCID: PMC4657947

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