Article
Risks of Hemolysis in Glucose-6-Phosphate Dehydrogenase Deficient Infants Exposed to Chlorproguanil-Dapsone, Mefloquine and Sulfadoxine-Pyrimethamine as Part of Intermittent Presumptive Treatment of Malaria in Infants.
PloS one - 1 Jan 2015
Poirot Eugenie, Vittinghoff Eric, Ishengoma Deus, Alifrangis Michael, Carneiro Ilona, Hashim Ramadhan, Baraka Vito, Mosha Jacklin, Gesase Samwel, Chandramohan Daniel, Gosling Roland
Abstract excerpt
BACKGROUND: Chlorproguanil-dapsone (CD) has been linked to hemolysis in symptomatic glucose-6-phosphate dehydrogenase deficient (G6PDd) children. Few studies have explored the effects of G6PD status on hemolysis in children treated with Intermittent Preventive Treatment in infants (IPTi) antimalarial regimens. We sought to examine the joint effects of G6PD status and IPTi antimalarial treatment on incidence of...
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