Article
Human pegivirus 2 exhibits minimal geographic and temporal genetic diversity.
Virology - 2 Jan 2020
Forberg Kenn, Rodgers Mary A, Dawson George J, Sauleda Silvia, Olivo Ana, Vallari Ana, Bes Marta, Piron Maria, Cloherty Gavin A, Berg Michael G
Abstract excerpt
We applied an NGS based target capture approach to amplify HPgV-2 sequences from metagenomic libraries and enable full genome characterization. Despite expanded geographical sampling, sequence variability remains low, with diversity concentrated in approximately 3.3% of all amino acids. Serial samples from one HPgV-2 positive individual co-infected with comparable titers of HIV, HCV, and GBV-C showed that HPgV-2...
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