Article
Rhinovirus Load Is High despite Preserved Interferon-β Response in Cystic Fibrosis Bronchial Epithelial Cells.
PloS one - 1 Jan 2015
Dauletbaev Nurlan, Das Mithun, Cammisano Maria, Chen He, Singh Sareen, Kooi Cora, Leigh Richard, Beaudoin Trevor, Rousseau Simon, Lands Larry C
Abstract excerpt
Lung disease in cystic fibrosis (CF) is often exacerbated following acute upper respiratory tract infections caused by the human rhinovirus (HRV). Pathophysiology of these exacerbations is presently unclear and may involve deficient innate antiviral or exaggerated inflammatory responses in CF airway epithelial cells. Furthermore, responses of CF cells to HRV may be adversely affected by pre-exposure to virulence...
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