Article
Antiviral immunity is impaired in COPD patients with frequent exacerbations.
American journal of physiology. Lung cellular and molecular physiology - 1 Dec 2019
Singanayagam Aran, Loo Su-Ling, Calderazzo Maria, Finney Lydia J, Trujillo Torralbo Maria-Belen, Bakhsoliani Eteri, Girkin Jason, Veerati Punnam, Pathinayake Prabuddha S, Nichol Kristy S, Reid Andrew, Footitt Joseph, Wark Peter A B, Grainge Christopher L, Johnston Sebastian L, Bartlett Nathan W, Mallia Patrick
Abstract excerpt
Patients with frequent exacerbations represent a chronic obstructive pulmonary disease (COPD) subgroup requiring better treatment options. The aim of this study was to determine the innate immune mechanisms that underlie susceptibility to frequent exacerbations in COPD. We measured sputum expression of immune mediators and bacterial loads in samples from patients with COPD at stable state and during...
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