CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.

doi:10.3171/2015.6.JNS15795

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Article

CYP2C19 and CES1 polymorphisms and efficacy of clopidogrel and aspirin dual antiplatelet therapy in patients with symptomatic intracranial atherosclerotic disease.

Journal of neurosurgery - 1 Jun 2016

Hoh Brian L, Gong Yan, McDonough Caitrin W, Waters Michael F, Royster Adrienne J, Sheehan Tiffany O, Burkley Ben, Langaee Taimour Y, Mocco J, Zuckerman Scott L, Mummareddy Nishit, Stephens Marcus L, Ingram Christie, Shaffer Christian M, Denny Joshua C, Brilliant Murray H, Kitchner Terrie E, Linneman James G, Roden Dan M, Johnson Julie A

Abstract excerpt

OBJECT Symptomatic intracranial atherosclerotic disease (ICAD) has a high risk of recurrent stroke. Genetic polymorphisms in CYP2C19 and CES1 are associated with adverse outcomes in cardiovascular patients, but have not been studied in ICAD. The authors studied CYP2C19 and CES1 single-nucleotide polymorphisms (SNPs) in symptomatic ICAD patients. METHODS Genotype testing for CYP2C19*2, (*)3, (*)8, (*)17 and CES1...

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Identifiers

PMID: 26587656
DOI: 10.3171/2015.6.JNS15795
PMCID: PMC4915569

Genes

CES1

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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