Article
Longitudinal anatomic, functional, and molecular characterization of Pick disease phenotypes.
Neurology - 15 Dec 2020
Whitwell Jennifer L, Tosakulwong Nirubol, Schwarz Christopher C, Senjem Matthew L, Spychalla Anthony J, Duffy Joseph R, Graff-Radford Jon, Machulda Mary M, Boeve Bradley F, Knopman David S, Petersen Ronald C, Lowe Val J, Jack Clifford R, Dickson Dennis W, Parisi Joseph E, Josephs Keith A
Abstract excerpt
OBJECTIVE: To characterize longitudinal MRI and PET abnormalities in autopsy-confirmed Pick disease (PiD) and determine how patterns of neurodegeneration differ with respect to clinical syndrome. METHODS: Seventeen patients with PiD were identified who had antemortem MRI (8 with behavioral variant frontotemporal dementia [bvFTD-PiD], 6 with nonfluent/agrammatic primary progressive aphasia [naPPA-PiD], 1 with...
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