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Hypoxia-inducible factor-1 alpha as a therapeutic target for primary effusion lymphoma

18 Sept 2017

Abstract excerpt

Primary effusion lymphoma (PEL) is an aggressive B-cell lymphoma with poor prognosis caused by Kaposi's sarcoma-associated herpesvirus (KSHV).Previous studies have revealed that HIF-1α, which mediates much of the cellular response to hypoxia, plays an important role in life cycle of KSHV.KSHV infection promotes HIF-1α activity, and several KSHV genes are in turn activated by HIF-1α.In this study, we investigated...

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PMID: 28922425
DOI: 10.1371/journal.ppat.1006628

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