Article
Identification of a Classical Mutant in the Industrial Host Aspergillus niger by Systems Genetics: LaeA Is Required for Citric Acid Production and Regulates the Formation of Some Secondary Metabolites.
G3 (Bethesda, Md.) - 13 Nov 2015
Niu Jing, Arentshorst Mark, Nair P Deepa S, Dai Ziyu, Baker Scott E, Frisvad Jens C, Nielsen Kristian F, Punt Peter J, Ram Arthur F J
Abstract excerpt
The asexual filamentous fungus Aspergillus niger is an important industrial cell factory for citric acid production. In this study, we genetically characterized a UV-generated A. niger mutant that was originally isolated as a nonacidifying mutant, which is a desirable trait for industrial enzyme production. Physiological analysis showed that this mutant did not secrete large amounts of citric acid and oxalic...
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