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Clinical significance of bax/bcl-2 ratio in chronic lymphocytic leukemia

12 Nov 2015

Abstract excerpt

In chronic lymphocytic leukemia the balance between the pro-apoptotic and anti-apoptotic members of the bcl-2 family is involved in the pathogenesis, chemorefractoriness and clinical outcome. Moreover, the recently proposed anti-bcl-2 molecules, such as ABT-199, have emphasized the potential role of of bcl-2 family proteins in the context of target therapies. We investigated bax/bcl-2 ratio by flow cytometry in...

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PMID: 26565002
DOI: 10.3324/haematol.2015.131854

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