Article
Calcineurin Inhibitors Downregulate HNF-1β and May Affect the Outcome of HNF1B Patients After Renal Transplantation.
Transplantation - 1 Sept 2016
Faguer Stanislas, Esposito Laure, Casemayou Audrey, Pirson Yves, Decramer Stéphane, Cartery Claire, Hazzan Marc, Garrigue Valérie, Roussey Gwenaelle, Cointault Olivier, Ho Thien, Merville Pierre, Devuyst Olivier, Gourdy Pierre, Chassaing Nicolas, Bascands Jean-Loup, Kamar Nassim, Schanstra Joost-Peter, Rostaing Lionel, Chauveau Dominique
Abstract excerpt
BACKGROUND: Patients with HNF1B mutations develop progressive chronic renal failure, diabetes mellitus (40-50%), and liver tests abnormalities (40-70%). In HNF1B patients who reach end-stage renal disease, single kidney transplantation (SKT) or combined kidney-pancreas transplantation can be considered. METHODS: A retrospective multicenter study including 18 HNF1B patients receiving SKT or kidney-pancreas...
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