Article
Targeting CD146 with a 64Cu-labeled antibody enables in vivo immunoPET imaging of high-grade gliomas.
Proceedings of the National Academy of Sciences of the United States of America - 24 Nov 2015
Yang Yunan, Hernandez Reinier, Rao Jun, Yin Li, Qu Yazhuo, Wu Jinrong, England Christopher G, Graves Stephen A, Lewis Christina M, Wang Pu, Meyerand Mary E, Nickles Robert J, Bian Xiu-Wu, Cai Weibo
Abstract excerpt
Given the highly heterogeneous character of brain malignancies and the associated implication for its proper diagnosis and treatment, finding biomarkers that better characterize this disease from a molecular standpoint is imperative. In this study, we evaluated CD146 as a potential molecular target for diagnosis and targeted therapy of glioblastoma multiforme (GBM), the most common and lethal brain malignancy....
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