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Article

Neural crest requires Impdh2 for development of the enteric nervous system, great vessels, and craniofacial skeleton.

Developmental biology - 1 Jan 2016

Lake Jonathan I, Avetisyan Marina, Zimmermann Albert G, Heuckeroth Robert O

Abstract excerpt

Mutations that impair the proliferation of enteric neural crest-derived cells (ENCDC) cause Hirschsprung disease, a potentially lethal birth defect where the enteric nervous system (ENS) is absent from distal bowel. Inosine 5' monophosphate dehydrogenase (IMPDH) activity is essential for de novo GMP synthesis, and chemical inhibition of IMPDH induces Hirschsprung disease-like pathology in mouse models by reducing...

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Identifiers

PMID: 26546974
DOI: 10.1016/j.ydbio.2015.11.004
PMCID: PMC4862663

Genes

IMPDH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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