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Article

Hox Genes Promote Neuronal Subtype Diversification through Posterior Induction in Caenorhabditis elegans.

Neuron - 4 Nov 2015

Zheng Chaogu, Diaz-Cuadros Margarete, Chalfie Martin

Abstract excerpt

Although Hox genes specify the differentiation of neuronal subtypes along the anterior-posterior axis, their mode of action is not entirely understood. Using two subtypes of the touch receptor neurons (TRNs) in C. elegans, we found that a "posterior induction" mechanism underlies the Hox control of terminal neuronal differentiation. The anterior subtype maintains a default TRN state, whereas the posterior subtype...

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Identifiers

PMID: 26539892
DOI: 10.1016/j.neuron.2015.09.049
PMCID: PMC4635444

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