EFN-4/Ephrin converges with SAX-3/Robo, UNC-6/Netrin, and Heparan Sulfate Proteoglycan signaling to control MAB-5/Hox-dependent posterior Q neuroblast migration in Caenorhabditis elegans.

doi:10.1371/journal.pgen.1012303

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EFN-4/Ephrin converges with SAX-3/Robo, UNC-6/Netrin, and Heparan Sulfate Proteoglycan signaling to control MAB-5/Hox-dependent posterior Q neuroblast migration in Caenorhabditis elegans.

PLoS genetics - 1 Sept 2026

Jain Vedant D, Johannesen Andrew M, Teixeira Felipe L, Lundquist Erik A

Abstract excerpt

Hox genes have been broadly implicated in nervous system development, but the molecular and genetic mechanisms that act downstream of Hox factors remain to be identified. The MAB-5 antennapedia-like Hox transcription factor is both necessary and sufficient to cause posterior migration of the Q neuroblast descendants in Caenorhabditis elegans. In response to MAB-5, the left-side QL descendants QL.a and QL.ap...

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Topics

Animals
Caenorhabditis elegans Proteins
Caenorhabditis elegans
Cell Movement
Signal Transduction
Nerve Tissue Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Heparan Sulfate Proteoglycans

Netrins

Roundabout Proteins

Gene Expression Regulation, Developmental

Neurons

Neural Stem Cells

Mutation

Transcription Factors

Homeodomain Proteins

Source

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Identifiers

PMID: 42709880
DOI: 10.1371/journal.pgen.1012303
PMCID: PMC13581211

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