Article
Large-scale sequencing of human influenza reveals the dynamic nature of viral genome evolution.
Nature - 20 Oct 2005
Ghedin Elodie, Sengamalay Naomi A, Shumway Martin, Zaborsky Jennifer, Feldblyum Tamara, Subbu Vik, Spiro David J, Sitz Jeff, Koo Hean, Bolotov Pavel, Dernovoy Dmitry, Tatusova Tatiana, Bao Yiming, St George Kirsten, Taylor Jill, Lipman David J, Fraser Claire M, Taubenberger Jeffery K, Salzberg Steven L
Abstract excerpt
Influenza viruses are remarkably adept at surviving in the human population over a long timescale. The human influenza A virus continues to thrive even among populations with widespread access to vaccines, and continues to be a major cause of morbidity and mortality. The virus mutates from year to year, making the existing vaccines ineffective on a regular basis, and requiring that new strains be chosen for a new...
Topics
- Animals
- Evolution, Molecular
- Genome, Viral
- Hemagglutinin Glycoproteins, Influenza Virus
- History, 20th Century
- History, 21st Century
- Humans
- Influenza A virus
- Influenza Vaccines