Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant.

doi:10.1371/journal.pone.0064045

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Article

Compound heterozygous mutations in SLC30A2/ZnT2 results in low milk zinc concentrations: a novel mechanism for zinc deficiency in a breast-fed infant.

PloS one - 1 Jan 2013

Itsumura Naoya, Inamo Yasuji, Okazaki Fumiko, Teranishi Fumie, Narita Hiroshi, Kambe Taiho, Kodama Hiroko

Abstract excerpt

Zinc concentrations in breast milk are considerably higher than those of the maternal serum, to meet the infant's requirements for normal growth and development. Thus, effective mechanisms ensuring secretion of large amounts of zinc into the milk operate in mammary epithelial cells during lactation. ZnT2 was recently found to play an essential role in the secretion of zinc into milk. Heterozygous mutations of...

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PMID: 23741301
DOI: 10.1371/journal.pone.0064045
PMCID: PMC3669329

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

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