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Article

Phenylarsine Oxide Can Induce the Arsenite-Resistance Mutant PML Protein Solubility Changes.

International journal of molecular sciences - 25 Jan 2017

Jiang Yu Han, Chen Ye Jia, Wang Chao, Lan Yong Fei, Yang Chang, Wang Qian Qian, Hussain Liaqat, Maimaitiying Yasen, Islam Khairul, Naranmandura Hua

Abstract excerpt

Arsenic trioxide (As₂O₃) has recently become one of the most effective drugs for treatment of patient with acute promyelocytic leukemia (APL), and its molecular mechanism has also been largely investigated. However, it has been reported that As₂O₃ resistant patients are frequently found in relapsed APL after consolidation therapy, which is due to the point mutations in B-box type 2 motifs of promyelocytic...

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Identifiers

PMID: 28125064
DOI: 10.3390/ijms18020247
PMCID: PMC5343784

Genes

PML

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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