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Article

N-acetylcysteine inhibits in vivo oxidation of native low-density lipoprotein

5 Nov 2015

Abstract excerpt

Low-density lipoprotein (LDL) is non-atherogenic, while oxidized LDL (ox-LDL) is critical to atherosclerosis. N-acetylcysteine (NAC) has anti-atherosclerotic effect with largely unknown mechanisms. The present study aimed to determine if NAC could attenuate in vivo LDL oxidation and inhibit atherosclerosis. A single dose of human native LDL was injected intravenously into male C57BL/6 mice with and without NAC...

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PMID: 26536834
DOI: 10.1038/srep16339

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