Brazilian kefir fraction mitigates the Alzheimer-like phenotype in Drosophila melanogaster with β-amyloid overexpression model.

doi:10.1038/s41598-024-76601-9

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Brazilian kefir fraction mitigates the Alzheimer-like phenotype in Drosophila melanogaster with β-amyloid overexpression model.

Scientific reports - 26 Oct 2024

Malta Serena Mares, Rodrigues Tamiris Sabrina, Silva Matheus Henrique, Marquez Alexandre Souza, Ferreira Rafael Bernardes, do Prado Mascarenhas Fernanda Naves Araújo, Zanon Renata Graciele, Bernardes Lucas Matos Martins, Batista Letícia Leandro, da Silva Murillo Néia Thomaz, de Oliveira Santos Débora, Santos Ana Carolina Costa, Mendes-Silva Ana Paula, Spindola Foued Salmen, Ueira-Vieira Carlos

Abstract excerpt

Alzheimer's disease (AD) is a progressive neurodegenerative condition and the primary form of dementia among elderly people. The amyloidogenic hypothesis is the main theory that explains this phenomenon and describes the extracellular accumulation of amyloid beta (Aβ) peptides. Model organisms such as Drosophila melanogaster have been utilized to improve the understanding of this disease and its treatment. This...

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PMID: 39461991
DOI: 10.1038/s41598-024-76601-9
PMCID: PMC11513133

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